New study unveils the mechanisms of 3 inhibitors to an important human drug metabolizing enzyme Researchers from the Structural and Molecular Biology research group at UCIBIO-FCT NOVA, have just published a new study describing a new crystal structure of the complex human aldehyde oxidase and its most potent inhibitor raloxifene, widely used in biochemical assays. This structure elucidates the unusual substrate-dependent mechanism of inhibition with potential impact on drug–drug interactions.
UCIBIO has been awarded 13 fellowships in the call "Verão com Ciência 2021" “Verão com Ciência” is a special support launched by Fundação para a Ciência e Tecnologia (FCT) to provide special support for scientific and technological research activities in R&D units with a view to enhancing scientific and technological capacity and its relationship with higher education and society.
Research project funded to develop a new generation of enzymes for immunomodulation in cancer therapy Ana Luísa Carvalho, Angelina Palma, Maria João Romão and Eurico Cabrita, researchers from UCIBIO at FCT NOVA, integrate the consortium of the “GlycoMed - A new generation of enzymes for biofilm dispersion and immunomodulation in cancer” project that aims to develop a catalog
Dog food sold across Europe contains antibiotic-resistant bacteria, including “superbugs” found in hospital patients New research study developed by researchers from the BacT_Drugs lab at UCIBIO - Faculty of Pharmacy, University of Porto, reveals raw dog food to be a major source of antibiotic-resistant bacteria, making it an international public health risk. With some of the multidrug-resistant bacteria in raw dog food identical to those found in hospital patients in several different European countries, the researc