People

Filipa Marcelo

senior researcher

Position
Assistant Investigator (since 2016)
Email
filipa.marcelo@fct.unl.pt
Ciência Vitae

Recent publications

  • Lima, CDL; Coelho, H; Gimeno, A; Trovao, F; Diniz, A; Dias, JS; Jimenez-Barbero, J; Corzana, F; Carvalho, AL; Cabrita, EJ; Marcelo, F. 2021. Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. CHEMISTRY-A EUROPEAN JOURNAL, DOI: 10.1002/chem.202100800
  • Gabba, A; Bogucka, A; Luz, JG; Diniz, A; Coelho, H; Corzana, F; Canada, FJ; Marcelo, F; Murphy, PV; Birrane, G. 2021. Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. BIOCHEMISTRY, 60, DOI: 10.1021/acs.biochem.1c00009
  • Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazon, A; Marcelo, F; Jimenez-Oses, G; Jimenez-Barbero, J; Arda, A; Ereno-Orbea, J. 2020. Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, DOI: 10.1002/anie.202011015
  • de las Rivas, Matilde; Paul Daniel, Earnest James; Narimatsu, Yoshiki; Compañón, Ismael; Kato, Kentaro; Hermosilla, Pablo; Thureau, Aurélien; et al. 2020. Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. Nature Chemical Biology, 16(3), DOI: 10.1038/s41589-019-0444-x
  • Ana Diniz; Helena Coelho; Jorge SDias; Sandra JVliet; Jesús Jiménez‐Barbero; Francisco Corzana; Eurico JCabrita; Filipa Marcelo. 2019. The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose‐Type Lectin. Chemistry – A European Journal, 25(61), DOI: 10.1002/chem.201902780
  • de las Rivas, M; Daniel, EJP; Coelho, H; Lira-Navarrete, E; Raich, L; Companon, I; Diniz, A; Lagartera, L; Jimenez-Barbero, J; Clausen, H; Rovira, C; Marcelo, F; Corzana, F; Gerken, TA; Hurtado-Guerrero, R. 2018. Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4. ACS Central Science, 4, DOI: 10.1021/acscentsci.8b00488
  • de las Rivas, M; Lira-Navarrete, E; Daniel, EJP; Companon, I; Coelho, H; Diniz, A; Jimenez-Barbero, J; Peregrina, JM; Clausen, H; Corzana, F; Marcelo, F; Jimenez-Oses, G; Gerken, TA; Hurtado-Guerrero, R. 2017. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nature Communications, 8, DOI: 10.1038/s41467-017-02006-0
  • Coelho, H; Matsushita, T; Artigas, G; Hinou, H; Canada, FJ; Lo-Man, R; Leclerc, C; Cabrita, EJ; Jimenez-Barbero, J; Nishimura, S; Garcia-Martin, F; Marcelo, F. 2015. The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, DOI: 10.1021/jacs.5b06787

Main research interests

  • Glycosciences
  • Molecular Recognition
  • NMR
  • Glycosylation