Helena L. A. Vieira

Research Lab Leader

Assistant Professor (since 2019)
Phone number
Ciência Vitae

Recent publications

  • Figueiredo-Pereira, C; Villarejo-Zori, B; Cipriano, PC; Tavares, D; Ramirez-Pardo, I; Boya, P; Vieira, HLA. 2023. Carbon Monoxide Stimulates Both Mitophagy And Mitochondrial Biogenesis to Mediate Protection Against Oxidative Stress in Astrocytes. MOLECULAR NEUROBIOLOGY, DOI: 10.1007/s12035-022-03108-7
  • Inês Guerra Mollet; Catarina Martins; Miguel Ângelo-Dias; Carvalho AS; Kerman Aloria; Rune Matthiesen; M Viana-Baptista; LUIS MIGUEL BORREGO; Helena LAVieira. 2022. Pilot study in human healthy volunteers on the mechanisms underlying remote ischemic conditioning (RIC) – Targeting circulating immune cells and immune-related proteins. JOURNAL OF NEUROIMMUNOLOGY, DOI: 10.1016/j.jneuroim.2022.577847
  • Soares, NL; Paiva, I; Bravo, J; Queiroga, CSF; Melo, BF; Conde, SV; Romao, CC; Summavielle, T; Vieira, HLA. 2022. Carbon Monoxide Modulation of Microglia-Neuron Communication: Anti-Neuroinflammatory and Neurotrophic Role. MOLECULAR NEUROBIOLOGY, DOI: 10.1007/s12035-021-02643-z
  • Dias-Pedroso, D; Ramalho, JS; Sardao, VA; Jones, JG; Romao, CC; Oliveira, PJ; Vieira, HLA. 2021. Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells. MOLECULAR NEUROBIOLOGY, DOI: 10.1007/s12035-021-02630-4
  • Figueiredo-Pereira, C; Dias-Pedroso, D; Soares, NL; Vieira, HLA. 2020. CO-mediated cytoprotection is dependent on cell metabolism modulation. Redox Biology, 32, DOI: 10.1016/j.redox.2020.101470
  • Oliveira, Sara R.; Figueiredo-Pereira, Cláudia; Duarte, Carlos B.; Vieira, Helena L.A.. 2019. P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study. MOLECULAR NEUROBIOLOGY, 56, DOI: 10.1007/s12035-018-1302-7
  • Oudot, Carole; Gomes, Andreia; Nicolas, Valérie; Le Gall, Morgane; Chaffey, Philippe; Broussard, Cédric; Calamita, Giuseppe; Mastrodonato, Maria; Gena, Patrizia; Perfettini, Jean Luc; Hamelin, Jocelyne; Lemoine, Antoinette; Fischmeister, Rodolphe; Vieira, Helena L.A.; Santos, Claudia N.; Brenner, Catherine. 2019. CSRP3 mediates polyphenols-induced cardioprotection in hypertension. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 66, DOI: 10.1016/j.jnutbio.2019.01.001
  • Osório, Daniel Noronha; Viana-Soares, Ricardo; Marto, João Pedro; Mendonça, Marcelo D.; Silva, Hugo P.; Quaresma, Cláudia; Viana-Baptista, Miguel; Gamboa, Hugo; Vieira, Helena L. A.. 2019. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. BMC Cardiovascular Disorders, 19, DOI: 10.1186/s12872-019-1181-5
  • Almeida, Ana S.; Soares, Nuno L.; Sequeira, Catarina O.; Pereira, Sofia A.; Sonnewald, Ursula; Vieira, Helena L.A.. 2018. Improvement of neuronal differentiation by carbon monoxide: role of pentose phosphate pathway. Redox Biology, 17, DOI: 10.1016/j.redox.2018.05.004

Main research interests

  • Carbon monoxide as a gasotransmitter for promoting cytoprotection and homeostasis in Central Nervous System
  • Cerebral ischemia and reperfusion events – ischemic stroke and perinatal hypoxic-ischemic encephalopathy
  • Biomarker for stroke diagnostics
  • Implication of cell metabolism on cell survival and function, namely neuronal function, neuroinflammatory activity of microglia and astrocytic homeostasis
  • Biological role of carboxyhemoglobin (COHb) - potential protective function
  • Peroxisome biology and its implications in redox sihnaling, metabolism and inflammation
  • Crosstalk between apoptosis, autophagy and cell differentiation
  • Mitostasis – mitochondrial homeostasis – controlled balance between mitochondrial biogenesis, mitochondrial function and mitophagy (elimination of damaged mitochondria)
  • Molecular mechanisms underlying preconditioning-induced cytoprotection, in particular remote ischemic conditioning