Jorge Miguel de Ascenção Oliveira

Research Lab Leader

Assistant Professor (since 2011)
Personal Website
Ciência Vitae

Recent publications

  • Liliana MAlmeida; Brígida RPinho; Michael RDuchen; Jorge MAOliveira. 2022. The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases. BIOLOGICAL REVIEWS, DOI: 10.1111/brv.12860
  • Silva, RFO; Pinho, BR; Monteiro, NM; Santos, MM; Oliveira, JMA. 2022. Automated analysis of activity, sleep, and rhythmic behaviour in various animal species with the Rtivity software. Scientific Reports, 12, DOI: 10.1038/s41598-022-08195-z
  • Pinho, BR; Almeida, LM; Duchen, MR; Oliveira, JMA. 2021. Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation. LIFE SCIENCES, 285, DOI: 10.1016/j.lfs.2021.120009
  • Pinho, BR; Duarte, AI; Canas, PM; Moreira, PI; Murphy, MP; Oliveira, JMA. 2020. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice. FREE RADICAL BIOLOGY AND MEDICINE, 146, DOI: 10.1016/j.freeradbiomed.2019.11.021
  • Pinho, BR; Reis, SD; Hartley, RC; Murphy, MP; Oliveira, JMA. 2019. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. FREE RADICAL BIOLOGY AND MEDICINE, 130, DOI: 10.1016/j.freeradbiomed.2018.10.446
  • Soares, TR; Reis, SD; Pinho, BR; Duchen, MR; Oliveira, JMA. 2019. Targeting the proteostasis network in Huntington's disease. AGEING RESEARCH REVIEWS, 49, DOI: 10.1016/j.arr.2018.11.006
  • Reis, SD; Pinho, BR; Oliveira, JMA. 2017. Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. MOLECULAR NEUROBIOLOGY, 54, DOI: 10.1007/s12035-016-0120-z
  • Pinho, BR; Reis, SD; Guedes-Dias, P; Leitao-Rocha, A; Quintas, C; Valentao, P; Andrade, PB; Santos, MM; Oliveira, JMA. 2016. Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease. PHARMACOLOGICAL RESEARCH, 103, DOI: 10.1016/j.phrs.2015.11.024
  • Guedes-Dias, P; Pinho, BR; Soares, TR; de Proenca, J; Duchen, MR; Oliveira, JMA. 2016. Mitochondrial dynamics and quality control in Huntington's disease. NEUROBIOLOGY OF DISEASE, 90, DOI: 10.1016/j.nbd.2015.09.008
  • Guedes-Dias, P; de Proenca, J; Soares, TR; Leitao-Rocha, A; Pinho, BR; Duchen, MR; Oliveira, JMA. 2015. HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852, DOI: 10.1016/j.bbadis.2015.08.012

Main research interests

  • Neurobiology
  • Mitochondrial physiology
  • Functional Imaging