Vera Marisa Costa

senior researcher

Research Group
DL 57 Transitory Norm contract (since 2018)
Phone number
Ciência Vitae

Recent publications

  • Sousa, A; Azevedo, R; Costa, VM; Oliveira, S; Preguica, I; Viana, S; Reis, F; Almeida, A; Matafome, P; Dias-Pereira, P; Carvalho, F; Fernandes, E; Freitas, M. 2023. Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice. ARCHIVES OF TOXICOLOGY, 97, DOI: 10.1007/s00204-023-03558-5
  • Brandao, SR; Reis-Mendes, A; Duarte-Araujo, M; Neuparth, MJ; Rocha, H; Carvalho, F; Ferreira, R; Costa, VM. 2023. Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice. BIOMOLECULES, 13, DOI: 10.3390/biom13060921
  • Costa, VM; Capela, JP; Bastos, ML; Remiao, F; Varner, KJ; Duarte, JA; Carvalho, F. 2023. Study of the potential toxicity of adrenaline to neurons, using the SH-SY5Y human cellular model. Brazilian Journal of Pharmaceutical Sciences, 59, DOI: 10.1590/s2175-97902023e20467
  • Silva-Reis, SC; Sampaio-Dias, IE; Costa, VM; Correia, XC; Costa-Almeida, HF; Garcia-Mera, X; Rodriguez-Borges, JE. 2023. Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences. ACS Chemical Neuroscience, DOI: 10.1021/acschemneuro.2c00675
  • Costa, VM; Grando, LGR; Milandri, E; Nardi, J; Teixeira, P; Mladenka, P; Remiao, F. 2022. Natural Sympathomimetic Drugs: From Pharmacology to Toxicology. BIOMOLECULES, 12, DOI: 10.3390/biom12121793
  • Reis-Mendes, A; Carvalho, F; Remiao, F; Sousa, E; Bastos, MD; Costa, VM. 2022. Autophagy (but not metabolism) is a key event in mitoxantrone-induced cytotoxicity in differentiated AC16 cardiac cells. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-022-03363-6
  • Remiao, F; Carmo, H; Gomes, M; Silva, R; Costa, VM; Carvalho, F; Bastos, MD. 2022. The impact of video lecture capture on student attainment and achievement of intended learning outcomes. AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION, 22, DOI: 10.46542/pe.2022.221.843855
  • Branda, SR; Carvalho, F; Amado, F; Ferreira, R; Costa, VM. 2022. Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings. METABOLISM-CLINICAL AND EXPERIMENTAL, 134, DOI: 10.1016/j.metabol.2022.155250
  • Garcia, J; Carvalho, A; das Neves, RP; Malheiro, R; Rodrigues, DF; Figueiredo, PR; Bovolini, A; Duarte, JA; Costa, VM; Carvalho, F. 2022. Antidotal effect of cyclosporine A against alpha-amanitin toxicity in CD-1 mice, at clinical relevant doses. FOOD AND CHEMICAL TOXICOLOGY, 166, DOI: 10.1016/j.fct.2022.113198
  • Dias-Carvalho, A; Ferreira, M; Reis-Mendes, A; Ferreira, R; Bastos, ML; Fernandes, E; Sa, SI; Capela, JP; Carvalho, F; Costa, VM. 2022. Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-022-03261-x
  • Dionisio, F; Araujo, AM; Duarte-Araujo, M; Bastos, MD; de Pinho, PG; Carvalho, F; Costa, VM. 2022. Cardiotoxicity of cyclophosphamide's metabolites: an in vitro metabolomics approach in AC16 human cardiomyocytes. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-021-03204-y
  • Reis-Mendes, A; Padrao, AI; Duarte, JA; Goncalves-Monteiro, S; Duarte-Araujo, M; Remiao, F; Carvalho, F; Sousa, E; Bastos, ML; Costa, VM. 2021. Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice. BIOMOLECULES, 11, DOI: 10.3390/biom11111725
  • Serras, AS; Camoes, SP; Antunes, B; Costa, VM; Dionisio, F; Yazar, V; Vitorino, R; Remiao, F; Castro, M; Oliveira, NG; Miranda, JP. 2021. The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22, DOI: 10.3390/ijms222313072
  • Dias-Carvalho, A; Ferreira, M; Ferreira, R; Bastos, MD; Sa, SI; Capela, JP; Carvalho, F; Costa, VM. 2021. Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-021-03171-4
  • Brandao, SR; Reis-Mendes, A; Domingues, P; Duarte, JA; Bastos, ML; Carvalho, F; Ferreira, R; Costa, VM. 2021. Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model. TOXICOLOGY, 459, DOI: 10.1016/j.tox.2021.152852
  • Anjos, M; Fontes-Oliveira, M; Costa, VM; Santos, M; Ferreira, R. 2021. An update of the molecular mechanisms underlying doxorubicin plus trastuzumab induced cardiotoxicity. LIFE SCIENCES, 280, DOI: 10.1016/j.lfs.2021.119760
  • Reis-Mendes, A; Dores-Sousa, JL; Padrao, AI; Duarte-Araujo, M; Duarte, JA; Seabra, V; Goncalves-Monteiro, S; Remiao, F; Carvalho, F; Sousa, E; Bastos, ML; Costa, VM. 2021. Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice. PHARMACEUTICALS, 14, DOI: 10.3390/ph14060510
  • Soares, J; Costa, VM; Bastos, MD; Carvalho, F; Capela, JP. 2021. An updated review on synthetic cathinones. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-021-03083-3
  • Araujo, AM; Carvalho, M; Costa, VM; Duarte, JA; Dinis-Oliveira, RJ; Bastos, MD; de Pinho, PG; Carvalho, F. 2021. In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV). ARCHIVES OF TOXICOLOGY, 95, DOI: 10.1007/s00204-020-02949-2
  • Costa, VM; Capela, JP; Sousa, JR; Eleuterio, RP; Rodrigues, PRS; Dores-Sousa, JL; Carvalho, RA; Bastos, ML; Duarte, JA; Remiao, F; Almeida, MG; Varner, KJ; Carvalho, F. 2020. Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-020-02874-4
  • Rufino, AT; Costa, VM; Carvalho, F; Fernandes, E. 2020. Flavonoids as antiobesity agents: A review. MEDICINAL RESEARCH REVIEWS, DOI: 10.1002/med.21740
  • Soares, J; Costa, VM; Gaspar, H; Santos, S; Bastos, MD; Carvalho, F; Capela, JP. 2020. Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-020-02761-y
  • Rodrigues, DF; Costa, VM; Bastos, MDL; Carvalho, FD. 2019. Effects of alpha-amanitin in HepG2 cells are not prevented by drugs used in Amanita phalloides intoxications. TOXICOLOGY LETTERS, 314, DOI:
  • Soares, J; Costa, VM; Gaspar, H; Santos, S; Bastos, MD; Carvalho, F; Capela, JP. 2019. Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells. NEUROTOXICOLOGY, 75, DOI: 10.1016/j.neuro.2019.08.009
  • Garcia, J; Costa, VM; Bovolini, A; Duarte, JA; Rodrigues, DF; Bastos, MD; Carvalho, F. 2019. An effective antidotal combination of polymyxin B and methylprednisolone for alpha-amanitin intoxication. ARCHIVES OF TOXICOLOGY, 93, DOI: 10.1007/s00204-019-02426-5
  • Reis-Mendes, A; Carvalho, F; Remiao, F; Sousa, E; Bastos, MD; Costa, VM. 2019. The Main Metabolites of Fluorouracil. BIOMOLECULES, 9, DOI: 10.3390/biom9030098
  • Reis-Mendes A; Alves M; Carvalho F; Remião F; Bastos ML; Costa VM. 2018. Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells.. Interdisciplinary toxicology, DOI: 10.2478/intox-2018-0002
  • Mladenka, P; Applova, L; Patocka, J; Costa, VM; Remiao, F; Pourova, J; Mladenka, A; Karliickova, J; Jahodar, L; Voprsalova, M; Varner, KJ; Sterba, M. 2018. Comprehensive review of cardiovascular toxicity of drugs and related agents. MEDICINAL RESEARCH REVIEWS, 38, DOI: 10.1002/med.21476
  • Feio-Azevedo, R; Costa, VM; Barbosa, DJ; Teixeira-Gomes, A; Pita, I; Gomes, S; Pereira, FC; Duarte-Araujo, M; Duarte, JA; Marques, F; Fernandes, E; Bastos, ML; Carvalho, F; Capela, JP. 2018. Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. ARCHIVES OF TOXICOLOGY, 92, DOI: 10.1007/s00204-018-2226-8
  • Almeida D; Pinho R; Correia V; Soares J; Bastos ML; Carvalho F; Capela JP; Costa VM. 2018. Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A 'Chemobrain' In Vitro Study.. Pharmaceuticals (Basel, Switzerland), DOI: 10.3390/ph11020041
  • Hrynchak, I; Sousa, E; Pinto, M; Costa, VM. 2017. The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs. DRUG METABOLISM REVIEWS, 49, DOI: 10.1080/03602532.2017.1316285
  • Rodrigues, D; Freitas, M; Costa, VM; Lopez-Quintela, MA; Rivas, J; Freitas, P; Carvalho, F; Fernandes, E; Silva, P. 2017. Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles. Nanotoxicology, 11, DOI: 10.1080/17435390.2017.1291865
  • Boeing, JS; Ribeiro, D; Chiste, RC; Visentainer, JV; Costa, VM; Freitas, M; Fernandes, E. 2017. Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress. FOOD CHEMISTRY, 220, DOI: 10.1016/j.foodchem.2016.09.188
  • Feio-Azevedo, R; Costa, VM; Ferreira, LM; Branco, PS; Pereira, FC; Bastos, ML; Carvalho, E; Capela, JP. 2017. Toxicity of the amphetamine metabolites 4-hydroxyamphetamine and 4-hydroxynorephedrine in human dopaminergic differentiated SH-SY5Y cells. TOXICOLOGY LETTERS, 269, DOI: 10.1016/j.toxlet.2017.01.012
  • Reis-Mendes, A; Gomes, AS; Carvalho, RA; Carvalho, F; Remiao, F; Pinto, M; Bastos, ML; Sousa, E; Costa, VM. 2017. Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy. ARCHIVES OF TOXICOLOGY, 91, DOI: 10.1007/s00204-016-1839-z
  • Teixeira-Gomes, A; Costa, VM; Feio-Azevedo, R; Duarte, JA; Duarte-Araujo, M; Fernandes, E; Bastos, MD; Carvalho, F; Capela, JP. 2016. "Ecstasy" toxicity to adolescent rats following an acute low binge dose. BMC Pharmacology & Toxicology, 17, DOI: 10.1186/s40360-016-0070-0
  • Couto, D; Freitas, M; Costa, VM; Chiste, RC; Almeida, A; Lopez-Quintela, MA; Rivas, J; Freitas, P; Silva, P; Carvalho, F; Fernandes, E. 2016. Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity. JOURNAL OF APPLIED TOXICOLOGY, 36, DOI: 10.1002/jat.3323
  • Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2015. Inosine Strongly Enhances Proliferation of Human C32 Melanoma Cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K Pathways. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 116, DOI: 10.1111/bcpt.12280
  • Dores-Sousa, JL; Duarte, JA; Seabra, V; Bastos, MD; Carvalho, F; Costa, VM. 2015. The age factor for mitoxantrone's cardiotoxicity: Multiple doses render the adult mouse heart more susceptible to injury. TOXICOLOGY, 329, DOI: 10.1016/j.tox.2015.01.006
  • Teixeira-Gomes, A; Costa, VM; Feio-Azevedo, R; Bastos, MDL; Carvalho, F; Capela, JP. 2015. The neurotoxicity of amphetamines during the adolescent period. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 41, DOI: 10.1016/j.ijdevneu.2014.12.001
  • Garcia, J; Costa, VM; Baptista, P; Bastos, MD; Carvalho, F. 2015. Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 997, DOI: 10.1016/j.jchromb.2015.06.001
  • Garcia, J; Costa, VM; Costa, AE; Andrade, S; Carneiro, AC; Conceicao, F; Paiva, JA; de Pinho, PG; Baptista, P; Bastos, MD; Carvalho, F. 2015. Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report. TOXICON, 103, DOI: 10.1016/j.toxicon.2015.06.012
  • Garcia, J; Costa, VM; Carvalho, ATP; Silvestre, R; Duarte, JA; Dourado, DFAR; Arbo, MD; Baltazar, T; Dinis-Oliveira, RJ; Baptista, P; Bastos, MD; Carvalho, F. 2015. A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B. ARCHIVES OF TOXICOLOGY, 89, DOI: 10.1007/s00204-015-1582-x
  • Garcia, J; Costa, VM; Carvalho, A; Baptista, P; de Pinho, PG; Bastos, MD; Carvalho, F. 2015. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. FOOD AND CHEMICAL TOXICOLOGY, 86, DOI: 10.1016/j.fct.2015.09.008
  • Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2014. Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 140, DOI: 10.1007/s00432-014-1645-z
  • Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2014. The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 74, DOI: 10.1007/s00280-014-2557-y
  • Nogueira, TB; Araujo, SD; Carvalho, F; Pereira, FC; Fernandes, E; Bastos, ML; Costa, VM; Capela, JP. 2014. MODELING CHRONIC BRAIN EXPOSURE TO AMPHETAMINES USING PRIMARY RAT NEURONAL CORTICAL CULTURES. NEUROSCIENCE, 277, DOI: 10.1016/j.neuroscience.2014.07.009
  • Capela, JP; Araujo, SD; Costa, VM; Ruscher, K; Fernandes, E; Bastos, MD; Dirnagl, U; Meisel, A; Carvalho, F. 2013. The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. NEUROTOXICOLOGY, 34, DOI: 10.1016/j.neuro.2012.09.005
  • Costa, VM; Carvalho, F; Duarte, JA; Bastos, MD; Remiao, F. 2013. The Heart As a Target for Xenobiotic Toxicity: The Cardiac Susceptibility to Oxidative Stress. CHEMICAL RESEARCH IN TOXICOLOGY, 26, DOI: 10.1021/tx400130v
  • Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2013. Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma. BIOMEDICINE & PHARMACOTHERAPY, 67, DOI: 10.1016/j.biopha.2013.08.003
  • Ferreira, PS; Nogueira, TB; Costa, VM; Branco, PS; Ferreira, LM; Fernandes, E; Bastos, ML; Meisel, A; Carvalho, F; Capela, JP. 2013. "Neurotoxicity of ""ecstasy"" and its metabolites in human dopaminergic differentiated SH-SY5Y cells". TOXICOLOGY LETTERS, 216, DOI: 10.1016/j.toxlet.2012.11.015
  • Carvalho, M; Carmo, H; Costa, VM; Capela, JP; Pontes, H; Remiao, F; Carvalho, F; Bastos, MD. 2012. Toxicity of amphetamines: an update. ARCHIVES OF TOXICOLOGY, 86, DOI: 10.1007/s00204-012-0815-5
  • Rossato, LG; Costa, VM; Limberger, RP; Bastos, MD; Remiao, F. 2011. Synephrine: From trace concentrations to massive consumption in weight-loss. FOOD AND CHEMICAL TOXICOLOGY, 49, DOI: 10.1016/j.fct.2010.11.007
  • Costa, VM; Carvalho, F; Bastos, ML; Carvalho, RA; Carvalho, M; Remiao, F. 2011. Contribution of Catecholamine Reactive Intermediates and Oxidative Stress to the Pathologic Features of Heart Diseases. CURRENT MEDICINAL CHEMISTRY, 18, DOI:
  • Rossato, LG; Costa, VM; Firmo, E; Bastos, MDL; Palmeira, C; Remiao, F. 2011. Therapeutic concentrations of mitoxantrone elicit cytotoxic effects on H9c2 cells. TOXICOLOGY LETTERS, 205, DOI: 10.1016/j.toxlet.2011.05.216
  • Rossato, LG; Costa, VM; de Pinho, PG; Carvalho, F; Bastos, MD; Remiao, F. 2011. Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes. ARCHIVES OF TOXICOLOGY, 85, DOI: 10.1007/s00204-010-0630-9
  • Rossato, LG; de Pinho, PG; Silva, R; Carmo, H; Carvalho, F; Bastos, MD; Costa, VM; Remiao, F. 2010. Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 52, DOI: 10.1016/j.jpba.2010.02.022
  • Costa, VM; Silva, R; Ferreira, R; Amado, F; Carvalho, F; de Lourdes Bastos, M; Carvalho, RA; Carvalho, M; Remião, F. 2009. Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. TOXICOLOGY, 257(1-2), DOI: 10.1016/j.tox.2008.12.010
  • Oliveira, SJ; Pinto, JP; Picarote, G; Costa, VM; Carvalho, F; Rangel, M; de Sousa, M; de Almeida, SF. 2009. ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity. PLoS One, 4, DOI: 10.1371/journal.pone.0006618
  • Costa, VM; Ferreira, LM; Branco, PS; Carvalho, F; Bastos, ML; Carvalho, RA; Carvalho, M; Remiao, F. 2009. Cross-Functioning between the Extraneuronal Monoamine Transporter and Multidrug Resistance Protein 1 in the Uptake of Adrenaline and Export of 5-(Glutathion-S-yl)adrenaline in Rat Cardiomyocytes. CHEMICAL RESEARCH IN TOXICOLOGY, 22, DOI: 10.1021/tx8002577

Main research interests

  • Cardio-oncology
  • Chemobrain
  • Drugs of abuse