Research Lab
Pharmaceutical Technology
29692
Research Highlights
Drug delivery and patient health
Different approaches employed to improve Central Nervous System (CNS) targeting, especially the use of nanocarriers, are highlighted. The development of lipid nanoparticles loaded with riluzole and functionalized with lactoferrin to improve targeting efficiency, enhance BBB penetration and increase drug delivery to the brain, was carried out.
The nose-to-brain route has also been investigated to improve the management of neurological disorders. In this context, the quality-by-design (QbD) approach has been successfully applied to optimize nanostructured lipid carriers (NLC) formulations with the desired requisites for nose-to-brain delivery. The results are promising and are progressing towards in vitro and in vivo studies.
Tumor-targeted delivery systems, particularly antibody-conjugated nanoparticles, and hormone-conjugated nanoparticles intended, respectively, for gastric cancer and melanoma treatment, and their association with stimuli-responsive polymers have been developed and characterized.
The poor flow properties of powders (excipients and/or drugs) can cause many problems such as inconsistent powder filling, drug content variation and segregation in tablets, capsules and granulates during manufacturing. Its monitoring makes it possible to understand the phenomena that occur during manufacturing process and so these difficulties can be avoided or mitigated.
