Research Lab

Pharmaceutical Technology

Research Interests

The three main research areas are:

  1. Pharmaceutical Technology
  2. Modified Drug Delivery
  3. Cosmetics: design, safety and efficacy
Research Highlights
Drug delivery and patient health

The nose-to-brain delivery is one of our areas of interest, especially to improve the management of neurological disorders. The Quality by Design (QbD) approach has been successfully applied to optimize formulations of nanostructured lipid carriers (NLC) with the desired requisites for nose-to-brain delivery. The results of these promising experiments and are being follow up by in
vitro and in vivo studies.


Ana Catarina Silva, João Nuno Moreira, José Manuel Sousa Lobo and Hugo Almeida edited the book “Current Applications of Pharmaceutical Biotechnology” (included in the series Advances in Biochemical Engineering/Biotechnology). The book is on the 5th position of the top of most downloaded books (17k) from Springer Nature.


highlight 2020

Representative Projects

“Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents”, FCT-MCTES, Total funding: € 161,852, Madalena Magalhães Pinto (PI), Paulo Costa (MedTech).

Selected Publications

Vieira, ACC; Chaves, LL; Pinheiro, M; Lima, SC; Neto, PJR; Ferreira, D; Sarmento, B; Reis, S. 2021. Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages. CARBOHYDRATE POLYMERS, 252, DOI: 10.1016/j.carbpol.2020.116978
Campos, J. C., D. Cunha, D. C. Ferreira, S. Reis and P. J. Costa. 2021. Oromucosal precursors of in loco hydrogels for wound-dressing and drug delivery in oral mucositis: Retain, resist, and release. Materials Science and Engineering B-Advanced Functional Solid-State Materials, DOI: 10.1016/j.msec.2020.111413
Padrão, T., C. C. Coelho, P. Costa, N. Alegrete, F. J. Monteiro and S. R. Sousa. 2021. Combining local antibiotic delivery with heparinized nanohydroxyapatite/collagen bone substitute: A novel strategy for osteomyelitis treatment. Materials Science and Engineering B-Advanced Functional Solid-State Materials, DOI: 10.1016/j.msec.2020.111329
Filipa Sousa; Domingos Ferreira; Salette Reis; Paulo Costa. 2020. Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources. PHARMACEUTICALS, 13(9), DOI: 10.3390/ph13090248
Fonseca, D. F. S., P. C. Costa, I. F. Almeida, P. Dias‐Pereira, I. Correia‐Sá, V. Bastos, H. Oliveira, C. Vilela, A. J. D. Silvestre and C. S. R. Freire. 2020. Swellable Gelatin Methacryloyl Microneedles for Extraction of Interstitial Skin Fluid toward Minimally Invasive Monitoring of Urea. MACROMOLECULAR BIOSCIENCE, DOI: 10.1002/mabi.202000195