Nanoactuators for Therapy and Diagnosis
Jesús M. de la Fuente, Instituto de Nanociencia y Materiales de Aragón, CSIC-Universidad de Zaragoza & CIBER-BBN, Spain
Host: Pedro Viana Baptista, UCIBIO-NOVA
ZOOM link: https://bit.ly/GuestSeminarsUCIBIO
ID da reunião: 865 7786 0516
Senha: 805165
Abstract: In the last decades, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science, engineering, physics, or chemistry. The very different properties compared to that of the respective bulk, and thus intriguing characteristics of materials in the nanometer scale, have driven nanoscience to be the center of many basic and applied research topics. Moreover, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of magnetic and gold nanoparticles as therapeutic and diagnosis tools against cancer.
Gold nanoprisms (NPRs) have been functionalized with PEG, glucose, cell penetrating peptides, antibodies and/or fluorescent dyes, aiming to enhance NPRs stability, cellular uptake, and imaging capabilities, respectively. Cellular uptake and impact were assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination, these nanoprobes can cause apoptosis. Moreover, these nanoparticles have also been used for optoacoustic imaging, as well as for tumoral marker detection using a novel type of thermal ELISA and LFIA nanobiosensor using a thermosensitive support.
Short CV: Prof. Jesús Martínez de la Fuente (Barakaldo, 1975) created his own research group (BIONANOSURF Group) at the Univ of Zaragoza in 2007, becoming internationally recognized in nanomaterials and biofunctionalization. The multidisciplinary nature of the group facilitates research and development in numerous areas, including biosensors, gene therapy, magnetism, photochemistry, surface chemistry and molecular metal oxides, among others. He has extensive experience in the synthesis and characterization of novel nanomaterials and their biofunctionalization for the use and development of the next generation of nanobiosensors and nanotherapeutics. In 2009, he founded the spin-off Nanoimmunotech SL. He has also been a pioneer in the application of gold nanoparticles in gene therapy and he has developed a methodology for the use of gold nanoparticles functionalized with carbohydrates (glyconanoparticles) for the study of biological processes (embryogenesis, cancer, inflammation, etc.). He has been PI of research projects with a total budget of more than 6 M€. 75% of this budget is derived from European projects (1 ERANET (Coord); 1 ERC-StG (Coord), 1 ERC-POC (Coord), 7 MSCA-IOF/IEF/IF (Coord), 1 ENMII, 1 TRANSCANII (Coord), 1 FP7, 3 H2020-NMBP); 10% comes from collaborations with companies (CASEN-FLEET, ORPHAN DRUG-RECORDATI, MECWINS, NB, NIT, PROTEOMIKA, BSH, VIRBAC); and the remaining 15% comes from research projects of national calls. In 2010 he was awarded the Aragón Investiga prize "Young Researchers". In 2013 he was awarded by the Shanghai Administration with the 1000 Talent Plan program to be a visiting professor at the Jiao Tong University of Shanghai. Since 2014, he is a permanent researcher at the Instituto de Nanociencia y Materiales de Aragon-CSIC.