GuestSeminars
217-D & Zoom Session
Add to Calendar 2024-10-18 13:00:00 2024-10-18 14:00:00 GuestSeminars@UCIBIO | Otília Vieira How lysosomal dysfunction impact mitochondria in the context of atherosclerosis: the role of iron Otília Vieira, NOVA Medical School, Universidade NOVA de Lisboa, Portugal   Hosts: Helena Vieira, UCIBIO-NOVA FCT   ROOM 217-D, Departamental Building at NOVA FCT ZOOM link: https://ucibio.pt/l/GuestSeminars   Abstract: Lysosomes, acidic, hydrolase-rich cellular organelles, are the final destination of endocytic and autophagic pathways. Cell homeostasis is vitally linked to lysosomal function; malfunction being associated with several chronic pathologies including atherosclerosis, the main cause of cardiovascular diseases. Lysosomes are involved in almost the whole process of atherosclerosis. We aim to contribute to the better understanding of these pivotal organelles in the biology/physiology and pathophysiology of atherosclerosis, with a particular focus on the lysosome-mitochondria membrane contact sites and their impact on iron metabolism.    Short Bio: I did my PhD on the "Effect of oxidized-LDL on endothelial-cell apoptosis and the protective effects of phenolic compounds". The work was done in the lab of Prof. R. Salvayre, Univ. Paul Sabatier, Toulouse and my co-supervisor was Prof. L. Almeida, at the Univ. of Coimbra. During my 1st post-doc, I worked on ¿Host-pathogen interactions¿ in the lab of Prof. S. Grinstein, at the Univ. of Toronto. My second post-doc was on ¿The TGN sorting of newly synthesized cargo in polarized cells¿ in the lab of Prof. K. Simons, at the MPI-CBG, Dresden. In 2006, I returned to Portugal to establish myself as an independent scientist at the Center for Neurosciences and Cell Biology at the Univ. of Coimbra. My group worked mainly on the mechanistic understanding of the process of plasma membrane resealing by lysosomes and its regulation during M. tuberculosis infection and on the use of surfactants as topical microbicides to prevent sexually transmitted infections. In 2014, I was awarded with the prestigious iFCT award at the consolidator level and moved to NOVA MEDICAL SCHOOL (NMS), New University of Lisbon, where I am the Principal Investigator of the group -Lysosomes and Disease (https://www.nms.unl.pt/en-us/Research/Research-Groups/Details/investigationgroupid/2219). In NMS taking advantage of my previous experience in atherosclerosis and membrane traffic I started a translational research project on cardiovascular diseases. The main objectives of my research are to identify the biochemical and cell biological etiology of atherosclerosis at the bench and to carry this knowledge through modern analytical chemical techniques to a clinical prediction of CVD risk. The team involved in my research includes cardiologists, molecular cell biologists and biophysical chemists. My group is composed of 1 senior scientist (that is in the World's Top 2% of the highly cited researchers worldwide), 1 assistant researcher, 2 PhD students and 2 research fellows. I have published a total of 50 articles in peer-reviewed journals, 12 as first author, 23 as last author and 25 as corresponding author in high impact journals such as PNAS, Nat. Cell Biol, J. Cell Biol, Matter and EBioMedicine. Four of my publications have been highlighted in the J Cell Biol, one in PNAS, one in EBioMedicine and three have been recommended in F1000Prime. Our J. Cell Biol. (2016) article  was highlighted in J. Cell Biol. and recommended twice in F1000. From the articles published during the last year, 2 were selected for covers of the journals (J. Lipid Res. and Traffic).  Excluding the "Guidelines for the use and interpretation of assays for monitoring autophagy" citations, my publications have been cited more than 5800 times and my h-factor is 33 (Google Scholar). According to Scopus my publications have been cited 5637 times and my h-factor is 31. Since 2006, I completed the supervision of 9 post-doctoral fellows, 7 PhD students and 3 MSc students. In competitive calls for funding, which included the creation of an international consortium with Harvard Medical School, USA, of which I was the coordinator, I have raised more than TWO Million euros. I was also awarded with 2 INOVC awards. In addition to my core scientific activities, I am also an Assistant Prof. with habilitation (Tenure Track) in NOVA MEDICAL SCHOOL where I teach more than 200 h/year. I am an Editor for Scientific Reports (Nature Publishing Group) and an Associate Editor for the Frontiers in Cell and Developmental Biology. I also act as examiner in MSc/PhD theses; and participate in peer- and grant proposal reviewing. I was member of the following H2020 consortiums: Twinning, RISE and COST Action. Presently, I am member of the Twinning on Extracellular Vesicles. I have also been involved in science dissemination events.  217-D & Zoom Session UCIBIO info@simbiose.com Europe/Lisbon public
otilia vieira

How lysosomal dysfunction impact mitochondria in the context of atherosclerosis: the role of iron

Otília Vieira, NOVA Medical School, Universidade NOVA de Lisboa, Portugal

 

Hosts: Helena Vieira, UCIBIO-NOVA FCT

 

ROOM 217-D, Departamental Building at NOVA FCT
ZOOM link: https://ucibio.pt/l/GuestSeminars

 

Abstract:

Lysosomes, acidic, hydrolase-rich cellular organelles, are the final destination of endocytic and autophagic pathways. Cell homeostasis is vitally linked to lysosomal function; malfunction being associated with several chronic pathologies including atherosclerosis, the main cause of cardiovascular diseases. Lysosomes are involved in almost the whole process of atherosclerosis. We aim to contribute to the better understanding of these pivotal organelles in the biology/physiology and pathophysiology of atherosclerosis, with a particular focus on the lysosome-mitochondria membrane contact sites and their impact on iron metabolism. 

 

Short Bio:

I did my PhD on the "Effect of oxidized-LDL on endothelial-cell apoptosis and the protective effects of phenolic compounds". The work was done in the lab of Prof. R. Salvayre, Univ. Paul Sabatier, Toulouse and my co-supervisor was Prof. L. Almeida, at the Univ. of Coimbra. During my 1st post-doc, I worked on ¿Host-pathogen interactions¿ in the lab of Prof. S. Grinstein, at the Univ. of Toronto. My second post-doc was on ¿The TGN sorting of newly synthesized cargo in polarized cells¿ in the lab of Prof. K. Simons, at the MPI-CBG, Dresden. In 2006, I returned to Portugal to establish myself as an independent scientist at the Center for Neurosciences and Cell Biology at the Univ. of Coimbra. My group worked mainly on the mechanistic understanding of the process of plasma membrane resealing by lysosomes and its regulation during M. tuberculosis infection and on the use of surfactants as topical microbicides to prevent sexually transmitted infections. In 2014, I was awarded with the prestigious iFCT award at the consolidator level and moved to NOVA MEDICAL SCHOOL (NMS), New University of Lisbon, where I am the Principal Investigator of the group -Lysosomes and Disease (https://www.nms.unl.pt/en-us/Research/Research-Groups/Details/investigationgroupid/2219). In NMS taking advantage of my previous experience in atherosclerosis and membrane traffic I started a translational research project on cardiovascular diseases. The main objectives of my research are to identify the biochemical and cell biological etiology of atherosclerosis at the bench and to carry this knowledge through modern analytical chemical techniques to a clinical prediction of CVD risk. The team involved in my research includes cardiologists, molecular cell biologists and biophysical chemists. My group is composed of 1 senior scientist (that is in the World's Top 2% of the highly cited researchers worldwide), 1 assistant researcher, 2 PhD students and 2 research fellows. I have published a total of 50 articles in peer-reviewed journals, 12 as first author, 23 as last author and 25 as corresponding author in high impact journals such as PNAS, Nat. Cell Biol, J. Cell Biol, Matter and EBioMedicine. Four of my publications have been highlighted in the J Cell Biol, one in PNAS, one in EBioMedicine and three have been recommended in F1000Prime. Our J. Cell Biol. (2016) article  was highlighted in J. Cell Biol. and recommended twice in F1000. From the articles published during the last year, 2 were selected for covers of the journals (J. Lipid Res. and Traffic).  Excluding the "Guidelines for the use and interpretation of assays for monitoring autophagy" citations, my publications have been cited more than 5800 times and my h-factor is 33 (Google Scholar). According to Scopus my publications have been cited 5637 times and my h-factor is 31. Since 2006, I completed the supervision of 9 post-doctoral fellows, 7 PhD students and 3 MSc students. In competitive calls for funding, which included the creation of an international consortium with Harvard Medical School, USA, of which I was the coordinator, I have raised more than TWO Million euros. I was also awarded with 2 INOVC awards. In addition to my core scientific activities, I am also an Assistant Prof. with habilitation (Tenure Track) in NOVA MEDICAL SCHOOL where I teach more than 200 h/year. I am an Editor for Scientific Reports (Nature Publishing Group) and an Associate Editor for the Frontiers in Cell and Developmental Biology. I also act as examiner in MSc/PhD theses; and participate in peer- and grant proposal reviewing. I was member of the following H2020 consortiums: Twinning, RISE and COST Action. Presently, I am member of the Twinning on Extracellular Vesicles. I have also been involved in science dissemination events. 

GuestSeminars@UCIBIO | Otília Vieira