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Add to Calendar 2024-06-27 15:00:00 2024-06-27 16:00:00 GuestSeminars@UCIBIO | Lara Mahal Adding a little sugar: How integrating glycomics brings new insights into multi’omic analysis Lara Mahal, Glycomics Institute of Alberta, University of Alberta, Canada   Hosts: Paula Videira, UCIBIO, NOVA   ZOOM link: https://ucibio.pt/l/GuestSeminars   Abstract: Glycans encode cellular information, including cell-cell interactions and cell state. However, glycosylation is often left out of multi’omic analysis. This talk focuses on the use of high-throughput analytical methods, including our lectin microarray technology, to bring new insights into the drivers of disease by integrating glycomics into multi’omic workflows. By focusing on clinical samples and relevant systems we are breaking new ground in areas including melanoma, pancreatic cancer, and host-response to pathogens, providing new targets for small molecule intervention in these disease states.   Short Bio: Lara K. Mahal is the Canada Excellence Research Chair in Glycomics,  Professor of Chemistry and Director of the Glycomics Institute of Alberta (GIA) at the University of Alberta. An expert in glycomics and chemical glycobiology, she developed lectin microarray technology, which provides a high-throughput method for glycomics now widely applied to understand systems from clinical cancer research to host-pathogen interactions. More recently, her work on microRNA regulation of glycosylation is overturning dogma on how these non-coding RNA work.  She obtained her Ph.D. in Chemistry at UC Berkeley (2000) with Professor Carolyn Bertozzi and was Jane Coffin Childs Postdoctoral Fellow in the laboratory of Professor James Rothman at Sloan-Kettering Institute (2000-2003). She started her first independent position as an Assistant Professor in Chemistry at the University of Texas at Austin in 2003.  Post-tenure in 2009, Professor Mahal moved to New York University, where she was faculty member from 2009-2019.  In September 2019, she joined the faculty of the University of Alberta as the CERC in Glycomics. In 2022, she founded the Glycomics Institute of Alberta. She has received numerous awards including the Arnold and Mabel Beckman Foundation Fellowship (2004), NSF Career Award (2007), Alfred P. Sloan Foundation Fellowship (2008), National Institutes of Health Director’s New Innovator Award (2008), the Horace Isbell Award for Carbohydrate Chemistry from the American Chemical Society (2017). Zoom Session UCIBIO info@simbiose.com Europe/Lisbon public
lara mahal

Adding a little sugar: How integrating glycomics brings new insights into multi’omic analysis

Lara Mahal, Glycomics Institute of Alberta, University of Alberta, Canada

 

Hosts: Paula Videira, UCIBIO, NOVA

 

ZOOM link: https://ucibio.pt/l/GuestSeminars

 

Abstract:

Glycans encode cellular information, including cell-cell interactions and cell state. However, glycosylation is often left out of multi’omic analysis. This talk focuses on the use of high-throughput analytical methods, including our lectin microarray technology, to bring new insights into the drivers of disease by integrating glycomics into multi’omic workflows. By focusing on clinical samples and relevant systems we are breaking new ground in areas including melanoma, pancreatic cancer, and host-response to pathogens, providing new targets for small molecule intervention in these disease states.

 

Short Bio:

Lara K. Mahal is the Canada Excellence Research Chair in Glycomics,  Professor of Chemistry and Director of the Glycomics Institute of Alberta (GIA) at the University of Alberta. An expert in glycomics and chemical glycobiology, she developed lectin microarray technology, which provides a high-throughput method for glycomics now widely applied to understand systems from clinical cancer research to host-pathogen interactions. More recently, her work on microRNA regulation of glycosylation is overturning dogma on how these non-coding RNA work.  She obtained her Ph.D. in Chemistry at UC Berkeley (2000) with Professor Carolyn Bertozzi and was Jane Coffin Childs Postdoctoral Fellow in the laboratory of Professor James Rothman at Sloan-Kettering Institute (2000-2003). She started her first independent position as an Assistant Professor in Chemistry at the University of Texas at Austin in 2003.  Post-tenure in 2009, Professor Mahal moved to New York University, where she was faculty member from 2009-2019.  In September 2019, she joined the faculty of the University of Alberta as the CERC in Glycomics. In 2022, she founded the Glycomics Institute of Alberta. She has received numerous awards including the Arnold and Mabel Beckman Foundation Fellowship (2004), NSF Career Award (2007), Alfred P. Sloan Foundation Fellowship (2008), National Institutes of Health Director’s New Innovator Award (2008), the Horace Isbell Award for Carbohydrate Chemistry from the American Chemical Society (2017).

GuestSeminars@UCIBIO | Lara Mahal