Seminars
Room 217D, Edifício Departamental - FCT NOVA
Add to Calendar 2019-12-11 12:00:00 2026-01-23 00:25:49 Helena Vieira | 10th Conference Cycle Helena Vieira, UCIBIO-FCT NOVA   Carbon monoxide against cerebral stroke: challenges and achievements   Chair: Maria João Romão, UCIBIO at FCT NOVA     Abstract   The seminar will give a brief introduction about our lab “Molecular Mechanisms of Disease” and the work we have been developing in the last 10 years. The main studied pathology is ischemic stroke, which results from the lack of blood supply (ischemia), limiting oxygen and nutrients availability. These events lead to brain damage and neuronal cell loss. Our broaden scientific question tackles the mechanisms underlying ischemia-reperfusion events in brain cells, by targeting several cellular processes: apoptosis, inflammation, autophagy, metabolic shifts, redox signaling and neuronal differentiation. The final objective is to integrate this knowledge and develop new approaches for protecting brain tissue based on: (i) the cytoprotective function of carbon monoxide /heme-oxygenase and (ii) the activation of endogenous mechanisms of defense and conditioning-induced tolerance. Room 217D, Edifício Departamental - FCT NOVA UCIBIO info@simbiose.com Europe/Lisbon public
Helena Vieira

Helena Vieira, UCIBIO-FCT NOVA

 

Carbon monoxide against cerebral stroke: challenges and achievements

 

Chair: Maria João Romão, UCIBIO at FCT NOVA
 

 

Abstract

 

The seminar will give a brief introduction about our lab “Molecular Mechanisms of Disease” and the work we have been developing in the last 10 years. The main studied pathology is ischemic stroke, which results from the lack of blood supply (ischemia), limiting oxygen and nutrients availability. These events lead to brain damage and neuronal cell loss. Our broaden scientific question tackles the mechanisms underlying ischemia-reperfusion events in brain cells, by targeting several cellular processes: apoptosis, inflammation, autophagy, metabolic shifts, redox signaling and neuronal differentiation. The final objective is to integrate this knowledge and develop new approaches for protecting brain tissue based on: (i) the cytoprotective function of carbon monoxide /heme-oxygenase and (ii) the activation of endogenous mechanisms of defense and conditioning-induced tolerance.

Helena Vieira | 10th Conference Cycle